Pathology of Gastrointestinal Stromal Tumors
نویسندگان
چکیده
منابع مشابه
Pathology of Gastrointestinal Stromal Tumors
Gastrointestinal stromal tumor (GIST) is a well recognized and relatively well understood soft tissue tumor. Early events in GIST development are activating mutations in KIT or PDGFRA, which occur in most GISTs and encode for mutated tyrosine receptor kinases that are therapeutic targets for tyrosine kinase inhibitors, including imatinib and sunitinib. A small minority of GISTs possessing neith...
متن کاملHistological and Immunological Evaluation of Gastrointestinal Stromal Tumors
Background: Gastrointestinal stromal tumors (GISTs) constitute the majority of gastrointestinal mesenchymal tumors. They usually express a proto-oncogen protein called CD117 detected by immunohistochemistry. This study investigated the differentiation of GISTs as well as the risk of aggressive behaviors in GISTs from surgically-treated patients in university affiliated hospitals. Methods: The c...
متن کاملPediatric gastrointestinal stromal tumors.
Gastrointestinal stromal tumors (GISTs) rarely occur in pediatric patients, but increased recognition of adult GIST has led to better awareness of the existence of this entity in the pediatric population. GIST occurring in pediatric patients has a unique biology and clinical behavior and warrants discussion as an independent entity. The generally accepted definition of pediatric GIST is a tumor...
متن کاملImaging gastrointestinal stromal tumors.
BACKGROUND Because of the recent reclassification of mesenchymal tumors, which was based on a better understanding of the genetics and immunophenotype of gastrointestinal stromal tumors (GISTs), only a limited number of studies have described the radiologic appearance of GISTs. METHODS This study reviews the imaging characteristics of GISTs, with an emphasis on differentiating benign and mali...
متن کاملGastrointestinal Stromal Tumors
Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. A relationship to the interstitial cells of Cajal (ICCs) has been proposed, and expression of CD117, the c-kit receptor present in ICCs, has been suggested as a marker for GISTs. Methods: The English literature has been reviewed with an emphasis on histogenetic features, esp...
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ژورنال
عنوان ژورنال: Clinical Medicine Insights: Pathology
سال: 2012
ISSN: 1179-5557,1179-5557
DOI: 10.4137/cpath.s9689